Early combination antibiotic therapy yields improved survival compared to monotherapy in septic shock: A propensity-matched analysis
نویسندگان
چکیده
Anand Kumar, MD; Ryan Zarychanski, MD; Bruce Light, MD; Joseph E. Parrillo, MD; Dennis Maki, MD; Dave Simon, MD; Denny Laporta, MD; Steve Lapinsky, MD; Paul Ellis, MD; Yazdan Mirzanejad, MD; Greg Martinka, MD; Sean Keenan, MD; Gordon Wood, MD; Yaseen Arabi, MD; Daniel Feinstein, MD; Aseem Kumar, PhD; Peter Dodek, MD; Laura Kravetsky, BSc; Steve Doucette, MSc; the Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group
منابع مشابه
Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis.
BACKGROUND Septic shock represents the major cause of infection-associated mortality in the intensive care unit. The possibility that combination antibiotic therapy of bacterial septic shock improves outcome is controversial. Current guidelines do not recommend combination therapy except for the express purpose of broadening coverage when resistant pathogens are a concern. OBJECTIVE To evalua...
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OBJECTIVE To assess whether a potential benefit with combination antibiotic therapy is restricted to the most critically ill subset of patients, particularly those with septic shock. DATA SOURCES OVID MEDLINE (1950-October 2009), EMBASE (1980-October 2009), the Cochrane Central Register of Controlled Trials (to third quarter 2009), the ClinicalTrial.gov database, and the SCOPUS database. ST...
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